Yes, especially on overstable mids where I need a flatter release or on any putter that comes out of a fan grip. For me the bead creates a sensory irritation when it digs across my grip, and whether it truly does or not, I always feel like the bead is going to catch on the meaty part of my fingerpads.
Can you force yourself to get used to it? Sure. I throw Rocs, Ghosts, and Roc3s and they all have beads. I have gotten used to them. But with everything else the bead very much can be the deciding factor whether I throw it or not regardless of how it otherwise flies.
For example, I normally could muddle through a round with my Axis, hitting some amazing shots, but I cannot use it a second round. Either the bead from that disc has irritated my hand enough where it does not sit comfortably in my grip, and thus affecting the throw, or just by throwing so much in general my hand is irritated and the way the Axis bead sits across that irritation makes it too uncomfortable to get a reliable and consistent throw. The last tournament that I seriously threw the Axis, I carded a 960 round for the first time out, but the second round was a horrific disaster at 890, all because I lost all comfort throwing the Axis. I have since switched over to throwing beefy Champ Leopards low to the ground for those same lines and the cleaner release has tremendously helped.