My predictions:
FD in stock S/C/D-line plus Night Strike 4 (in a different plastic).
P2 in stock S/D/P-line plus Sky God 4 (yet another plastic type? or cycle back to C-line?) - other than D-line probably won't overlap with Omega4/Alpaca/Firefly plastics (stiff ET/Color Glow DT/MF glow & color glow C-Blend/Nexus)
DD3 in stock S/C-lines (new!) plus Cloudbreaker 3 (remain swirly S-Line), maybe a special edition (metalflake?)
MD3/PD might be one or both. Depends if they make Iron Samurai III, Lone Howl III, Dark Maul III. If they are produced, expect all the stock plastics (S/C/D) and maybe an additional special edition.
I'd say the above are the 5 most popular molds currently in the Originals lineup and make sense for the limited amount of production time. I think everyone would be happy with more availability of the tour series discs so they will likely increase production of those and do bigger runs of the stock plastics for each.
Likely no PD2/FD2/FD3 Tour series so those won't get produced (they were produced in 2020 though). Simon moving on to the Tilt seems to replace the Sky Rider?
Could see Montgomery & Pirronen's Tour series moving over to the Evo line (Link/Instinct?) and Klein, Anttila, & Vikstrom getting a tour series in the Evo line (maybe one of the new molds?). Avery may not get a tour series disc (similar to Dana losing the Roaming Thunder CD2).